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Thoracic Oncology Lab »  People »  Principal Investigators »  Csaba J. Peto, Ph.D.
Csaba J. Peto, Ph.D.

Csaba J. Peto, Ph.D.

  • Associate Professor of Surgery
  • Division of Adult Cardiothoracic Surgery
  • Thoracic Oncology Program

Contact Information

Thoracic Oncology Laboratory
UCSF Helen Diller Family Comprehensive Cancer Center
2340 Sutter St, Room N225
San Francisco, CA 94143-1724
[email protected]
 
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Education

University of Debrecen, Hungary, B.S., Biology & Chemistry, 1989

University of Debrecen, Hungary Ph.D., Organic Chemistry, 1997

Research Interests

  • Carbohydrate based therapeutics.
  • Small molecule kinase inhibitors

Biography

Csaba J. Peto, Ph.D. joined the Thoracic Oncology Laboratory in January 2013 as a synthetic medicinal chemist. His primary research focus is the discovery and development of small molecule drug candidates for cancer therapy. Previous to his appointment as a specialist at UCSF, Dr. Peto has has twenty years of experience in the biotech industry, notably at Tualrik and Exelixis.  

Research Overview

Dr. Peto designs and synthesizes compounds for multi parametric optimization. During his tenure at Exelixis, Inc., Dr. Peto played a key role in research and development of orally available, small molecule kinase inhibitors that target oncogenic signaling pathways, identifying five development candidates (IND), of which four entered into clinical trials, most notably GDC-0973, a small molecule MEK inhibitor.

Csaba J Peto Phd

Publications

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  1. Lemjabbar-Alaoui H, Peto CJ, Yang YW, Jablons DM. AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers. Am J Cancer Res. 2020; 10(8):2649-2676. View in PubMed
  2. Liu S, Hsieh D, Yang YL, Xu Z, Peto C, Jablons DM, You L. Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2. BMC Pharmacol Toxicol. 2013 Jul 11; 14:36. View in PubMed
  3. Bussenius J, Blazey CM, Aay N, Anand NK, Arcalas A, Baik T, Bowles OJ, Buhr CA, Costanzo S, Curtis JK, DeFina SC, Dubenko L, Heuer TS, Huang P, Jaeger C, Joshi A, Kennedy AR, Kim AI, Lara K, Lee J, Li J, Lougheed JC, Ma S, Malek S, Manalo JC, Martini JF, McGrath G, Nicoll M, Nuss JM, Pack M, Peto CJ, Tsang TH, Wang L, Womble SW, Yakes M, Zhang W, Rice KD. Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90. Bioorg Med Chem Lett. 2012 Sep 01; 22(17):5396-404. View in PubMed
  4. Rice KD, Aay N, Anand NK, Blazey CM, Bowles OJ, Bussenius J, Costanzo S, Curtis JK, Defina SC, Dubenko L, Engst S, Joshi AA, Kennedy AR, Kim AI, Koltun ES, Lougheed JC, Manalo JC, Martini JF, Nuss JM, Peto CJ, Tsang TH, Yu P, Johnston S. Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973). ACS Med Chem Lett. 2012 May 10; 3(5):416-21. View in PubMed

 

 
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