Developing Novel Therapeutics for Treatment of Mesothelioma and Lung Cancer Metastasis

Principal Investigator: Liang You, Ph.D.

The goal of this project is to test potential therapeutics for mesothelioma in our newly developed Cullin 4A (Cul4A)-midiated metastasis model in which mouse mesothelioma cells are directly injected into the pleural cavity of immune-competent mice and to better understand the role of Hippo/YAP signaling pathways in Cul4A-mediated mouse mesothelioma metastasis. This builds on past work in collaboration with Dr. Jian-Hua Mao, Dr. Zhidong Xu, Dr. Yi-Lin Yang, and Dr.  David Jablons that investigated the role of Cul4A in genomic instability and tumor development.